منابع مشابه
Delivery strategies to achieve therapeutic myocardial angiogenesis.
The use of recombinant genes or growth factors to enhance myocardial collateral blood vessel function may represent a new approach to the treatment of cardiovascular disease. Proof of concept has been demonstrated in animal models of myocardial ischemia, and clinical trials are underway. Currently, it is unknown which is the safest and most effective delivery strategy to induce clinically impor...
متن کاملTherapeutic Myocardial Angiogenesis Via Vascular Endothelial Growth Factor Gene Therapy
Amid the criticisms levied at gene therapy researchers recently, the positive (yet preliminary) advances in therapies designed to elicit angiogenesis for the treatment of ischemic vascular disease, such as the current report by Vale and colleagues,1 are a breath of fresh air for cardiovascular specialists and their patients. Although therapeutic angiogenesis is still in its nascent stages (and ...
متن کاملTherapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery.
In this manuscript, we describe the potential role of the pericardial space as a drug delivery reservoir to administer angiogenic agents to the heart resulting in functionally significant angiogenesis with single bolus basic fibroblast growth factor (bFGF) delivery. We also describe a percutaneous subxyphoid pericardial access technique that is safe, rapid, and reliable.
متن کاملTherapeutic angiogenesis.
Therapeutic angiogenesis constitutes a fundamental survival mechanism that acts to preserve the integrity of tissues subjected to ischemia. Supplemental administration of angiogenic cytokines--as recombinant protein or plasmid DNA--have been shown to augment collateral development when endogenous angiogenesis is suboptimal for organ function, and thus constitute a novel therapeutic option for t...
متن کاملTherapeutic Angiogenesis
Vascular endothelial growth factor (VEGF) is a heparin-binding, endothelial cell-specific mitogen. Previous studies have suggested thatVEGF is a regulator ofnaturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis that the angiogenic potential of VEGF is sufficient to constitute a therapeutic effect. The soluble 165amino acid isoform ofVEGF was a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microvascular Research
سال: 2007
ISSN: 0026-2862
DOI: 10.1016/j.mvr.2007.08.005